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MYP_095502
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Basic Information
Caerin-1.9 (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C124H205N31O29
Standard
Sequence
GLFGVLGSIAKHVLPHVVPVIAEKL
Physicochemical Analysis
2594.14 Da
8.61
0.94
0.63
0.0374
1.15
0.43
0.47
29.32
159.60
0.0400
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
911.07
-3.17
30.0
32.0
82.0
184.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0204586 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
GDM1.441
7.5 μg/mL
MIC
PMID34259550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34259550/
RECORD: Rec_0222279 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0235080 VERIFIED: YES
Provenance & Taxonomy
Ranoidea chloris [Animal]
Frog skin active peptide (FSAP); Caerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Non-hemolytic
PMID9516047;11784303 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9516047/
RECORD: Rec_0237029 VERIFIED: YES
Provenance & Taxonomy
Chlorohyla chloris [Animal]
Caerin
3681102
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV Infection inhibition
Human immunodeficiency virus (HIV) | T cells
1.2 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperAntimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. | VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. | J Virol. 2005 Sep;79(18):11598-606. | DOI:10.1128/JVI.79.18.11598-11606.2005 | PMID:16140737 PMID16140737 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
RECORD: Rec_0261523 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
inhibition of HIV transfer by dendritic cells to T cells
1.6 μM
IC50
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID26026377;16140737;15203252;9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
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