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MYP_095502
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Basic Information
Caerin-1.9 (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C124H205N31O29
Standard
Sequence
GLFGVLGSIAKHVLPHVVPVIAEKL
Physicochemical Analysis
2594.14 Da
8.61
0.94
0.63
0.0374
1.15
0.43
0.47
29.32
159.60
0.0400
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
911.07
-3.17
30.0
32.0
82.0
184.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000573 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells
4 μM
IC50
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID26026377;16140737;15203252;9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0006658 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
Listeria innocua
50 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID26026377;16140737;15203252;9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0033684 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
Micrococcus luteus
50 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID26026377;16140737;15203252;9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0038696 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0041576 VERIFIED: YES
Provenance & Taxonomy
Litoria chloris [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID26026377;16140737;15203252;9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
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