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MYP_095485
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Basic Information
Endothelin-1
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
21 amino acids
C109H163N25O32S5
Standard
Sequence
CSCSSLMDKECVYFCHLDIIW
Physicochemical Analysis
2495.93 Da
4.54
-2.19
-2.51
-0.1043
0.63
0.26
0.24
59.44
88.10
0.1429
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
908.63
-5.79
36.0
36.0
79.0
171.0
5.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0367113 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1517
RECORD: Rec_0382556 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Endothelin/sarafotoxin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Vasoactive Hormone
PMID2451132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2451132/
RECORD: Rec_0398661 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Endothelin
10090
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
glomerular mesangial cells
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Mus musculus): PMID 2182027 PMID2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2182027/
RECORD: Rec_0402915 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
1-15, 3-11
Bio-Activity Profile
Drug Delivery Vehicle Blood-Brain Barrier
PaperBrainpeps: the blood-brain barrier peptide database PMID22205159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22205159/
RECORD: Rec_0413704 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Endothelin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Homo sapiens): PMID 2182027 PMID2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2182027/
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