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MYP_095485
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Basic Information
Endothelin-1
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
21 amino acids
C109H163N25O32S5
Standard
Sequence
CSCSSLMDKECVYFCHLDIIW
Physicochemical Analysis
2495.93 Da
4.54
-2.19
-2.51
-0.1043
0.63
0.26
0.24
59.44
88.10
0.1429
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
908.63
-5.79
36.0
36.0
79.0
171.0
5.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0295645 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Endothelin
10116
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Rattus norvegicus): PMID 2182027 PMID2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2182027/
RECORD: Rec_0297276 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Endothelin
9823
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Myotropic Receptor modulation ACE inhibitory
glomerular mesangial cells
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Sus scrofa): PMID 2665739##2182027 PMID2665739;2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2665739/
RECORD: Rec_0329865 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
endothelin/sarafotoxin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone endothelin sarafotoxin family Chemokine-like Growth factor signaling
PaperPDB 1V6R structural record; NMR; chain A; residues 1-21
RECORD: Rec_0357249 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Endothelin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Vasoconstricting peptide
Radioimmunoassay and RP-HPLC
Purified ET-1 protein sample, in vitro; 2220 s
PMID7529108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529108/
RECORD: Rec_0362071 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Endothelin/sarafotoxin
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Vasoactive Hormone
PMID2451132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2451132/
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