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MYP_095485
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Basic Information
Endothelin-1
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
21 amino acids
C109H163N25O32S5
Standard
Sequence
CSCSSLMDKECVYFCHLDIIW
Physicochemical Analysis
2495.93 Da
4.54
-2.19
-2.51
-0.1043
0.63
0.26
0.24
59.44
88.10
0.1429
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
908.63
-5.79
36.0
36.0
79.0
171.0
5.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005480 VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Endothelin
9615
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Canis lupus familiaris): PMID 2182027 PMID2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2182027/
RECORD: Rec_0009273 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Endothelin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
glomerular mesangial cells
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Homo sapiens): PMID 2182027 PMID2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2182027/
RECORD: Rec_0011759 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Endothelin
9823
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Myotropic Receptor modulation ACE inhibitory
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Sus scrofa): PMID 2665739##2182027 PMID2665739;2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2665739/
RECORD: Rec_0015921 VERIFIED: YES
Provenance & Taxonomy
Atelerix albiventris [Animal]
Endothelin
9368
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Receptor modulation
Experimental: 40 seconds; /40 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Endothelin-1 (Atelerix albiventris): PMID 2182027 PMID2182027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2182027/
RECORD: Rec_0038348 VERIFIED: NO
Provenance & Taxonomy
Sus scrofa [Animal]; Bos taurus [Animal]; Canis familiaris [Animal]; Cavia porcellus [Animal]; Homo sapiens [Animal]; Mus musculus [Animal]; Oryctolagus cuniculus [Animal]; Rattus norvegicus [Animal]
9823, 9913, 9615, 10141, 9606, 10090, 9986, 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Neuropeptide
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