Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length264 amino acids

Chemical FormulaC1333H2119N333O388S5

DescriptionStandard

        MEKPILRNLNEILCPIITSEVEALNANLSVLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPIVLPERSDSMLYIGLSKYFFKSASFAYFTAGAFNVTLSTKEISSHLIPNSQGLGSMLSRVASTSVGLVILGQRLICSLSLNRFRLSLPESSRGSIEVLRFENILSSIIHFGVLPLANAKLQQGFPLPHPHKISFVNSDVEVLEDLLLISTNLKYETSLKQPPSFPGWADLNLISRQLSGKPAP
    

Molecular Weight29178.41 Da

Isoelectric Point (pI)5.61

Net Charge (pH 7.0)-4.14

Net Charge (pH 7.4) -4.64

Charge Density (pH 7.0) -0.0157

GRAVY Index0.18

Hydrophobic Moment 0.77

Boman Index0.16

Instability Index47.57

Aliphatic Index 115.19

Aromaticity 0.0833

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 17545.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0189263 VERIFIED: NO

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyBPI

Tax ID9796

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence