Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length164 amino acids

Chemical FormulaC792H1263N225O233S5

DescriptionStandard

        ACQEGTRVLQQQLSTIHMPDFSGSTRIGHIKAKYSFNSMVVRKFQLPSSQISLVPNVGLKLTISGAFIEVDGKWKAHYLVSASGGFDLKVEGLSISVGLQLGSDASGRPTISPSDCSCHISDVKVHVSGKFGWLVDVFHKSVDKALRNAIEKQVRTGDHNIRSF
    

Molecular Weight17825.19 Da

Isoelectric Point (pI)9.41

Net Charge (pH 7.0)6.38

Net Charge (pH 7.4) 5.76

Charge Density (pH 7.0) 0.0389

GRAVY Index-0.09

Hydrophobic Moment 0.79

Boman Index0.06

Instability Index53.92

Aliphatic Index 90.24

Aromaticity 0.0732

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7349.43

LogP -80.61

H-bond Donors 260.0

H-bond Acceptors 251.0

Rotatable Bonds 599.0

Heavy Atoms 1255.0

Ring Count 26.0

Amide Bonds 175.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086005 VERIFIED: YES

Provenance & Taxonomy

OrganismHymenochirus boettgeri [Animal]

Tax ID247094

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria