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MYP_095345
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Basic Information
Api760
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XWXRPVYXPRPRPPHPRL
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014304 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu = N
unspecified non-canonical residue at 1,3,8; N,N,N',N'-tetramethylguanidino, C-terminal OH, X= L-ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae DSM 681
8 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0027379 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
None
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa(DSM 3227)
256 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0072094 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu = N
unspecified non-canonical residue at 1,3,8; N,N,N',N'-tetramethylguanidino, C-terminal OH, X= L-ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 3227
32 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0088566 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu = N
unspecified non-canonical residue at 1,3,8; N,N,N',N'-tetramethylguanidino, C-terminal OH, X= L-ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 9644
8 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0132207 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
None
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
50% MHB:Pseudomonas aeruginosa(DSM 1117)
16 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
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