Peptide Database

Peptide NameSLAY-screened peptide P2543

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC88H141N25O33S4

DescriptionStandard

        PRTMSYNSACTCSELNCLDP
    

Molecular Weight2205.47 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.07

Net Charge (pH 7.4) -1.17

Charge Density (pH 7.0) -0.0534

GRAVY Index-0.40

Hydrophobic Moment 0.17

Boman Index-0.08

Instability Index83.79

Aliphatic Index 44.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 937.50

LogP -13.76

H-bond Donors 36.0

H-bond Acceptors 36.0

Rotatable Bonds 68.0

Heavy Atoms 150.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0120689 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/