Peptide Database

Peptide NameAPTEDB-DTX (Fibronectin extra domain B (EDB)-specific aptide docetaxel conjugate)

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC135H200N38O38S2

DescriptionStandard

        CSSPIQGSWTWENGKPRPARGYLGLYC
    

Molecular Weight3027.39 Da

Isoelectric Point (pI)8.86

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0644

GRAVY Index-0.68

Hydrophobic Moment 0.46

Boman Index-0.01

Instability Index15.59

Aliphatic Index 47.04

Aromaticity 0.1481

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1219.81

LogP -12.57

H-bond Donors 45.0

H-bond Acceptors 42.0

Rotatable Bonds 90.0

Heavy Atoms 213.0

Ring Count 9.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0325527 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsModified Gly at 16th postion i.e. propargylglycine and peptide conjugated with drug DTX at this position

Bio-Activity Profile

Function

Anticancer

MethodHPLC

Half-LifeC57BL6 mice Serum, in vivo; 1767.6 s