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MYP_095269
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Basic Information
CPXV012
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
34 amino acids
C204H303N55O48S2
Standard
Sequence
QEGISRFKICPYHWYKQHMSLLFRRYYHKLDSII
Physicochemical Analysis
4358.06 Da
9.65
4.01
3.63
0.1179
-0.59
0.67
-0.08
71.96
80.29
0.2059
11460.00
11460.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1682.81
-8.54
62.0
57.0
142.0
309.0
12.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0030380 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID32872420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32872420/
RECORD: Rec_0087715 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of virus replication in LC5-RIC reporter cells
100 μg/mL
% inhibition
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperA Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope. | Luteijn RD, Praest P, Thiele F, Sadasivam SM, Singethan K, Drijfhout JW, Bach C, de Boer SM, Lebbink RJ, Tao S, Helfer M, Bach NC, Protzer U, Costa AI, Killian JA, Drexler I, Wiertz EJHJ. | Cells. 2020 Aug 29;9(9):1989. | DOI:10.3390/cells9091989 | PMID:32872420 PMID32872420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32872420/
RECORD: Rec_0106883 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-RVFV Infection inhibition
Rift Valley fever virus (RVFV) | MJS cells
160 μg/mL
% inhibition
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperA Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope. | Luteijn RD, Praest P, Thiele F, Sadasivam SM, Singethan K, Drijfhout JW, Bach C, de Boer SM, Lebbink RJ, Tao S, Helfer M, Bach NC, Protzer U, Costa AI, Killian JA, Drexler I, Wiertz EJHJ. | Cells. 2020 Aug 29;9(9):1989. | DOI:10.3390/cells9091989 | PMID:32872420 PMID32872420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32872420/
RECORD: Rec_0187436 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Infection inhibition
HIV-1 | reporter cells
100 μg/mL
% inhibition
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperA Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope. | Luteijn RD, Praest P, Thiele F, Sadasivam SM, Singethan K, Drijfhout JW, Bach C, de Boer SM, Lebbink RJ, Tao S, Helfer M, Bach NC, Protzer U, Costa AI, Killian JA, Drexler I, Wiertz EJHJ. | Cells. 2020 Aug 29;9(9):1989. | DOI:10.3390/cells9091989 | PMID:32872420 PMID32872420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32872420/
RECORD: Rec_0212854 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Vero and Huh7
PMID32872420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32872420/
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