Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length479 amino acids

Chemical FormulaC2349H3682N584O686S20

DescriptionStandard

        MLPSVMAVFAILSCTSGETPAVQVTLTDKWLQYVKHVGAGWVQDMLEHITFPDISGDVDILIGHVDYTLSGIRITKCDLPEPVVEFYQQPTGLKTSIVGLSAALVGGWSTHFGLIHDGGSFDMAILSVSLTSVVQLGRDPEGHLSITSISCESQVGDVDIQFHGGASFIFQPFVDHFKGKIVGIIQSNICPNVQKAIDGVESHLKAMSVSYNVNEVLTVEFPLTGPPAISGADVNLGLKGEFYSIKTHQEPPFVAQPFVLPEQPDYMMSVGLSEFTLNSASFGYFSAGKFQVLINESMVPPKSPVHLNTTSMGMFIPQLPKQYPNMLMTLQVYATEAPMVSLQPDVGEVSAQFGAKAFAIEPNGTQVPLFTLNIETKLRSKMWIADGKLKGNAVLDNFTLTLASSEVGTFKTDALENVVKVGINLLGLPKLNALLGDGIFLPPMKQAQLVDPVLKVEKGFLAVSADMKIVQTSRNFNTL
    

Molecular Weight51721.16 Da

Isoelectric Point (pI)5.13

Net Charge (pH 7.0)-14.53

Net Charge (pH 7.4) -15.46

Charge Density (pH 7.0) -0.0303

GRAVY Index0.22

Hydrophobic Moment 0.59

Boman Index0.21

Instability Index36.30

Aliphatic Index 98.62

Aromaticity 0.0835

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35660.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420238 VERIFIED: NO

Provenance & Taxonomy

OrganismIconisemion striatum [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria