Peptide Database

Peptide NamePseA

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC120H167N31O39S6

DescriptionStandard

        GDCGGTCTWTKDCSICPSWSCWSWSC
    

Molecular Weight2860.18 Da

Isoelectric Point (pI)4.21

Net Charge (pH 7.0)-1.30

Net Charge (pH 7.4) -1.59

Charge Density (pH 7.0) -0.0499

GRAVY Index-0.15

Hydrophobic Moment 0.21

Boman Index0.14

Instability Index61.07

Aliphatic Index 15.00

Aromaticity 0.1538

Extinction Coeff. Reduced 22000.00

Extinction Coeff. Oxidized 22375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1107.65

LogP -14.38

H-bond Donors 47.0

H-bond Acceptors 44.0

Rotatable Bonds 82.0

Heavy Atoms 196.0

Ring Count 9.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0126428 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus pseudomycoides [Bacterium]; Bacteria [Bacterium]

Tax ID2; 2

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0239699 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus pseudomycoides [Bacterium]

FamilyBacteriocin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideDisulfide bond(s) reported

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetGram-positive

RECORD: Rec_0292825 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus pseudomycoides [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsThis antibiotic with four thioether rings and a disulfide bond. This bridges in this peptide have been further defined in a more recent paper: a disulfide bond between C3 and C7, four thioether bonds: T8-C13, T10-C16, S18-C21, S20-C26 (Janssen et al., 2022)

Bio-Activity Profile

Function

Antimicrobial

TargetBacillus subtilis (TMB016, TMB299, 416 TMB588), Streptococcus G 3643 ?0 ? all tested Staphylococcus aureus strains (Staphylococcus aureus SG511, Staphylococcus aureus 417 1000/93

RECORD: Rec_0339595 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antibacterial Antimicrobial Anti-Gram-positive