Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length447 amino acids

Chemical FormulaC2218H3497N591O629S8

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGITVLEKELAQLKLPDISGDFRIRHVGKVQYEISSLDLRSFHLPYSRISLVPKVGLQVSISNAFAELDGDWRVKLHFIRDHGSFDLRVENVYIKIDLKLGSDTSGKPTIDTSACSTRISKVQVHFSGKFGWLYNLFYGAVESRFRKILESKVCETVASSVSNDLQPYARTLPVTARIDAMAGINYSLVAPPTATAQSLDAGLKGEFFSLVHRSAVPFLPLPLALPPDHNRMVYFGASSYFLNTAGFAYHEAGALVFEITDSMIPKDVGFHLNTTTFSAFIPQLEKMYPDTLMKIRLSASSAPFLNIGPEGLSLKPVVDIQAYAILPDSSLAPLFLLSLVSNVSAVIDVKSGHIVGSLNVGRYGGGAVQGAPVRSLQSIMNILASSILLPRLNARLAEGFPLPLPDRIQLSNILVRFHQVSGGSPQPR
    

Molecular Weight48762.59 Da

Isoelectric Point (pI)9.01

Net Charge (pH 7.0)5.46

Net Charge (pH 7.4) 4.54

Charge Density (pH 7.0) 0.0122

GRAVY Index0.13

Hydrophobic Moment 0.66

Boman Index0.13

Instability Index38.75

Aliphatic Index 103.60

Aromaticity 0.0895

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0066935 VERIFIED: NO

Provenance & Taxonomy

OrganismCrotophaga sulcirostris [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria