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MYP_094918
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Basic Information
[Y7W, K8R, Y14W]cGm (Derived from Gm)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C94H155N39O21S4
Standard
Sequence
GCRRLCWRQRCVTWCRGR
Physicochemical Analysis
2295.75 Da
11.31
5.72
5.46
0.3178
-0.88
0.39
-0.57
43.15
37.78
0.1111
11000.00
11250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1024.32
-11.00
45.0
31.0
74.0
158.0
4.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0273468 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
2-15; 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Hemolytic
human red blood cells
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0341095 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0379299 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
16 μM
MIC
PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0403067 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
2-15; 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Hemolytic
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0416667 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
2-15; 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic
K-562
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
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