Peptide Database

Peptide NameHexastatin-2

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H163N33O32S2

DescriptionStandard

        YCNINEVCHYARRNDKSYWL
    

Molecular Weight2547.82 Da

Isoelectric Point (pI)8.03

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.54

Charge Density (pH 7.0) 0.0414

GRAVY Index-0.99

Hydrophobic Moment 0.64

Boman Index-0.24

Instability Index113.13

Aliphatic Index 58.50

Aromaticity 0.2000

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1095.30

LogP -9.61

H-bond Donors 41.0

H-bond Acceptors 36.0

Rotatable Bonds 80.0

Heavy Atoms 179.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0303058 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/

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