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MYP_094768
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Basic Information
Ranatuerin-6 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C67H108N14O16S
Standard
Sequence
FISAIASMLGKFL
Physicochemical Analysis
1397.72 Da
8.75
0.76
0.55
0.0584
1.68
0.49
0.60
2.70
135.38
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
479.00
-1.58
17.0
18.0
46.0
98.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0205681 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Staphylococcus aureus
100 μM
MIC
PaperRanatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana.
RECORD: Rec_0240917 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0273086 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Antiviral Antimicrobial Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0319777 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranatuerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
100 μM
MIC
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
RECORD: Rec_0405794 VERIFIED: NO
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Hemolytic Non-ribosomal
Qualitative functional evidence
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/; https://www.uniprot.org/uniprotkb/P82821/entry; https://bblserver.org.in/ampdb/
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