Peptide Database

Peptide NameAnalogue of Insulin like growth factor 1 (E3A/F49A)

Function Ontology

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC329H516N94O99S7

DescriptionStandard

        GPATLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
    

Molecular Weight7596.64 Da

Isoelectric Point (pI)8.31

Net Charge (pH 7.0)1.71

Net Charge (pH 7.4) 1.40

Charge Density (pH 7.0) 0.0244

GRAVY Index-0.20

Hydrophobic Moment 0.46

Boman Index-0.03

Instability Index67.51

Aliphatic Index 61.43

Aromaticity 0.1000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3089.63

LogP -34.65

H-bond Donors 114.0

H-bond Acceptors 108.0

Rotatable Bonds 243.0

Heavy Atoms 529.0

Ring Count 12.0

Amide Bonds 72.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366312 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyIGF

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsI125 radiolabeling

Bio-Activity Profile

Function

Growth regulation Cell proliferation regulation

Target5 days. Proteoglycan synthesis(matrix) synthesis is increased ~ 3 times in E3A/F49A treated sampleas compare to control as measured by scientillation counter

Activity0.04 μg/mL

MethodTCA precipitation

Half-LifeIntravenous injection into rat, in vivo; 115.2 s