Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length436 amino acids

Chemical FormulaC2090H3336N524O643S17

DescriptionStandard

        MLSLCCILALLALSCPETSGNTAGVKVKLTQKGLEYGRQIGVTTLLDQFKTIKVPDFSGSEEVSPIGKVSYSLTGIKVINVGLPQSEVALVPGTGVSLTISNAYINLHEKHANIFCANSKSPAYSYIKDEGENGSFDLAVSELSISTTVTIQSDDTGRPVVSSANCAASVGQTSVTFHGGASWLYNLFSSYIDDALRSVLQRKVKCYTVQSLVLAKVDQYAEIDYSMVESPVISTSSIDLSFNSAGFVYNNAGALSLRITDDMIPSSSPFRLNTKTFGTFIPQIAKQYPDLMMELLVKAATAPTVMFTPNNITLQANATVTAYAIQPNTTLTPLFILNVDASVSCQIYVTGVKVAGNLTLNAVNMTLGTSYVGPFEVKSLDSIFQMVLKAAVIPEVNALLQQGFPLPAIGEMNLVNTQLVIMKDYLLIGTDVQFTA
    

Molecular Weight46637.07 Da

Isoelectric Point (pI)5.09

Net Charge (pH 7.0)-7.28

Net Charge (pH 7.4) -7.84

Charge Density (pH 7.0) -0.0167

GRAVY Index0.28

Hydrophobic Moment 0.70

Boman Index0.20

Instability Index31.42

Aliphatic Index 103.05

Aromaticity 0.0780

Extinction Coeff. Reduced 29340.00

Extinction Coeff. Oxidized 29715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0382867 VERIFIED: NO

Provenance & Taxonomy

OrganismElectrophorus electricus [Animal]

FamilyBPI

Tax ID8005

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence