Peptide Database

Peptide NameBrevifactin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor

Standard StatusStandard

Sequence Length4 amino acids

Chemical FormulaC15H26N4O5

DescriptionStandard

        PLGG
    

Molecular Weight342.39 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.04

Net Charge (pH 7.4) -0.10

Charge Density (pH 7.0) -0.0104

GRAVY Index0.35

Hydrophobic Moment 0.13

Boman Index0.54

Instability Index38.35

Aliphatic Index 97.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 136.63

LogP -1.41

H-bond Donors 5.0

H-bond Acceptors 5.0

Rotatable Bonds 9.0

Heavy Atoms 24.0

Ring Count 1.0

Amide Bonds 3.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0047626 VERIFIED: YES

Provenance & Taxonomy

OrganismBrevibacterium aureum [Bacterium]

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermLipidation

Other ModsAttached by a hydrophobic moiety of octadecanoic (stearic) acid methyl ester at the C-terminus via forming an ester bond

Bio-Activity Profile

Function

Antimicrobial Antifungal Antioxidant

TargetStaphylococcus aureus, Klebsiella pneumoniae, Enterococcus faecalis, Staphylococcus epidermidis, Micrococcus luteus, Pseudomonas aeruginosa, Escherichia coli, P. mirabilis, S. streptococcus, Candida albicans. Warning: However, this molecule may also have undesired property to help bacterial biofilm formation.

RECORD: Rec_0401367 VERIFIED: NO