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MYP_094593
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Basic Information
AR-23 [A1,8R;I17K]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
23 amino acids
C117H205N37O28
Standard
Sequence
RIGSILGRLAKGLPTLKSWIKNR
Physicochemical Analysis
2578.11 Da
12.00
5.76
5.55
0.2503
-0.18
0.79
-0.08
15.24
123.04
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1078.06
-9.05
40.0
34.0
89.0
182.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0143782 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
In L929 cells, the cell viability is 96%, 95%, 92%, 68% and 31
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0168211 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
12.5 μM
MIC
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0184401 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus CGMCC 1.8721
100 μM
MIC
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0243211 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli CGMCC 1.8732
12.5 μM
MIC
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0271898 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
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