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MYP_094544
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Basic Information
Phakellistatin 2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IXPYPFP
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008542 VERIFIED: YES
Provenance & Taxonomy
Stylotella aurantium [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x=D-Allo-Ile
Bio-Activity Profile
Antimicrobial Anticancer
K562
3.2 μM
IC50
PMID12444643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12444643/
RECORD: Rec_0012876 VERIFIED: YES
Provenance & Taxonomy
Stylotella aurantium [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x=D-Allo-Ile
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
0.66 μM
IC50
PMID12444643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12444643/
RECORD: Rec_0071289 VERIFIED: YES
Provenance & Taxonomy
Stylotella aurantium [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x=D-Allo-Ile
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID12444643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12444643/
RECORD: Rec_0071472 VERIFIED: YES
Provenance & Taxonomy
Stylotella aurantium [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x=D-Allo-Ile
Bio-Activity Profile
Antimicrobial Anticancer
HCT 116
0.71 μM
IC50
PMID12444643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12444643/
RECORD: Rec_0106719 VERIFIED: YES
Provenance & Taxonomy
Stylotella aurantium [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x=D-Allo-Ile
Bio-Activity Profile
Antimicrobial Anticancer
(IC50=28.27 μg/ml (DMSO); IC50=2.72 μg/ml (MeOH))
PMID12444643 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12444643/
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