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MYP_094536
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Basic Information
Unnamed
Annotation / Sequence feature ▸ Nuclear export signal
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Metabolic ▸ Lipid metabolism ▸ Cholesterol-lowering
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
13 amino acids
C70H101N19O15S
Standard
Sequence
HPHPHLSFMAIPP
Physicochemical Analysis
1480.73 Da
7.02
0.02
-0.33
0.0017
-0.15
0.05
0.31
26.89
67.69
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
483.63
-1.76
14.0
19.0
37.0
105.0
8.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000445 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
kappa-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
IC50
PaperIn vitro and in silico evaluation of multifunctional properties of bioactive synthetic peptides identified in milk fermented with Lactococcus lactis NRRL B-50571 and NRRL B-50572 | Ma, R-R. et al. | DOI: 10.1016/j.lwt.2021.112581 Evidence URLhttps://www.uniprot.org/uniprotkb/P02668/entry
RECORD: Rec_0147928 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiamnestic
34.8
PaperHsieh C. H., Wang T. Y., Hung C. C., Hsieh Y. L., Hsu, K. C.. Isolation of prolyl endopeptidase inhibitory peptides from a sodium caseinate hydrolysate. Food & Function, 7(1), 565-573, 2016.
RECORD: Rec_0225450 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive Cholesterol-lowering Hypocholesterolemic
Spontaneously hypertensive rats (SHR)
PaperFermented Milk containing ACE-inhibitory peptides reduces blood pressure in middle aged hypertensive subjects
RECORD: Rec_0264938 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
0.076±0.4 μg/mL
IC50
PaperNovel angiotensin I-converting enzyme inhibitory peptides produced in fermented milk by specific wild Lactococcus lactis strains PMID22901481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22901481/
RECORD: Rec_0282760 VERIFIED: YES
Provenance & Taxonomy
bos taurus [Animal]
Casein-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory
prolyl endopeptidase
34.8 μM
IC50