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MYP_094517
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Basic Information
Ponericin-L2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C123H217N31O28
Standard
Sequence
LLKELWTKIKGAGKAVLGKIKGLL
Physicochemical Analysis
2578.23 Da
10.30
4.76
4.54
0.1982
0.40
0.50
0.18
-22.19
150.42
0.0417
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
962.06
-3.12
34.0
33.0
94.0
182.0
2.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0347974 VERIFIED: YES
Provenance & Taxonomy
Pachycondyla goeldii [Animal]; Insecta [Animal]
Ponericin
33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
RECORD: Rec_0348257 VERIFIED: YES
Provenance & Taxonomy
Pachycondyla goeldii [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
Bacillus cereus CIP 6624a(Inhibition zone = 6.5mm)
PaperPonericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9. doi: 10.1074/jbc.M100216200. PMID: 11279030. PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
RECORD: Rec_0358911 VERIFIED: YES
Provenance & Taxonomy
Pachycondyla goeldii [Animal]
Ponericin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Insecticidal
Staphylococcus aureus CIP 677 MRSA
2-85 μM
MIC
PaperPonericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
RECORD: Rec_0359612 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Insecticidal
Horse erythrocytes
400-500 μM
Inhibition zone
Paperhttps://pubmed.ncbi.nlm.nih.gov/11279030/ PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
RECORD: Rec_0370869 VERIFIED: YES
Provenance & Taxonomy
Pachycondyla goeldii [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm)
PaperPonericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9. doi: 10.1074/jbc.M100216200. PMID: 11279030. PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
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