Peptide Database

Peptide NameSC21EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC129H201N29O38

DescriptionStandard

        WEEWDKKIEEYTKKIEELIKK
    

Molecular Weight2766.15 Da

Isoelectric Point (pI)5.19

Net Charge (pH 7.0)-1.23

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0585

GRAVY Index-1.64

Hydrophobic Moment 0.69

Boman Index-0.35

Instability Index70.57

Aliphatic Index 74.29

Aromaticity 0.1429

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1134.58

LogP -3.51

H-bond Donors 39.0

H-bond Acceptors 37.0

Rotatable Bonds 100.0

Heavy Atoms 196.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0302851 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 HXB2:inhibition of cell-cell fusion in TZM-bl cells

Activity0.1054±0.0128 μM

MethodIC50

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0381854 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 HXB2 | TZM-bl cells

Activity0.1054±0.0128 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

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