Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2328H3666N590O658S19

DescriptionStandard

        KCEKMLYTWYSFLLCWMSLQLEANPGLKVRITQKGLDYGRKIGMELLKQAVLKETFPSWSGQENFSIVTVSYVMSKLRFNSVDFPETSASFIPGTGISLSVAHASATISADWRMNTWLLNDQGGITVSISGLFIAVIFKVSRDSTGCLSVLLHDCQLTINSVKVEFNGGSSWIYSFLSGYLEKPIHTKLDQNICQNIEYKIQMMDAHIRKQKVLRHIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGNHTDPPFVPAPFALPNQDDSMLYLGVSSYVLKSASLAYYRAGAFSITISEELATTFNLNIGLFKDFVPEIALSYKIACPVLLRLMATSPPAVSLNADRCILQITGCVEVFAVLPNSTTQYIFTGNLTASTRANLTITKQKLIISLLLKRLQFSLMHSPLRSSELTSLMENFLSYALWNTVIPIINDKLGKGFPLNLAHTTLAGPVIKINQ
    

Molecular Weight51056.80 Da

Isoelectric Point (pI)8.85

Net Charge (pH 7.0)7.48

Net Charge (pH 7.4) 6.61

Charge Density (pH 7.0) 0.0163

GRAVY Index0.20

Hydrophobic Moment 0.71

Boman Index0.17

Instability Index36.95

Aliphatic Index 104.50

Aromaticity 0.1000

Extinction Coeff. Reduced 62340.00

Extinction Coeff. Oxidized 62840.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0151938 VERIFIED: NO

Provenance & Taxonomy

OrganismDryobates pubescens [Animal]

FamilyBPI/LBP

Tax ID118200

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria