Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length186 amino acids

Chemical FormulaC949H1434N210O288S8

DescriptionStandard

        PMLIDDLAEVDYSLNSLPAVFQPFIDLDLKGIVYASGNYTVPPYVATPFTIPDQSDSMLYLAFSEYFFQTYSFAYYTAGAFNTTIAEETCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATEVPIISLEQDSFTVEIRGSMEVFAVLPDSTTQSLFTTNIAANTSIALNIFDQKLMGSLCLNR
    

Molecular Weight20649.29 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-14.04

Net Charge (pH 7.4) -14.17

Charge Density (pH 7.0) -0.0755

GRAVY Index0.31

Hydrophobic Moment 0.55

Boman Index0.25

Instability Index39.32

Aliphatic Index 93.87

Aromaticity 0.1398

Extinction Coeff. Reduced 17880.00

Extinction Coeff. Oxidized 18005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7864.09

LogP -84.80

H-bond Donors 269.0

H-bond Acceptors 282.0

Rotatable Bonds 651.0

Heavy Atoms 1455.0

Ring Count 38.0

Amide Bonds 199.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0167720 VERIFIED: NO

Provenance & Taxonomy

OrganismCentropus bengalensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria