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MYP_094324
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
36 amino acids
C195H298N52O68S
Standard
Sequence
WMEWDREINNYTSLIHSLIEESQNQQEKNEQELLEL
Physicochemical Analysis
4490.82 Da
4.14
-7.13
-7.40
-0.1981
-1.19
0.58
-0.18
67.72
86.67
0.0833
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2011.57
-18.44
66.0
63.0
156.0
316.0
6.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0349228 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition
Human immunodeficiency virus (HIV)
0.00704±0.00012 μM
IC90
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0400394 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
CEM
0.008 μg/mL
IC50
PaperMethods and compositions for treatment of HIV-1 infection using antiviral compounds in simultaneous or sequential combinations PatentUS6861059
RECORD: Rec_0425438 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition
Human immunodeficiency virus (HIV) | MT-2 cells
0.00467±0.00007 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
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