Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2443H3866N632O674S15

DescriptionStandard

        MARGPGSARRWAALVVLVALGTAVTTTTNPGIVARVTQKGLDHACQQGVLTLQKELEKITIPTFSGNFKIKYLGKGQYSFFSMVIQGFNLPNSQIRPLPDEGLDLSIRDASIKIRGKWKARKNFIKLGGNFDLSVEGISILAALSLGYDPDSGHSTVTCPRCSSHINTVRIRISGSSVGWLIQLFHKRIESSLQNSMTSKICEVVTSTVSSKLQPYFQTLPVTTKLDKVAGVDYSLVAPPRVTADNLDGLLKGEFFSLAHRSPPPFAPPALAFPTDHDRMVYLGISEYFFNTAGFVYQKAGALNLTLRDDMIPKESMFHLTTKFFGTLIPQVAKMFPDMQMQLFIWASLPPKLTVNPNGLNLIFVLDTQAFAILPNSSLDPLFLLEMNLNLSVVVGARSDRLIGELRLDKLLLELKHSDVGPFSVELLQSVMNYAVPTIVLPVINKKLQRGFPLPLPAYIKLFNLILQPYQDFLLFGADVHYS
    

Molecular Weight53355.63 Da

Isoelectric Point (pI)9.35

Net Charge (pH 7.0)11.27

Net Charge (pH 7.4) 10.44

Charge Density (pH 7.0) 0.0233

GRAVY Index0.14

Hydrophobic Moment 0.65

Boman Index0.14

Instability Index31.16

Aliphatic Index 103.93

Aromaticity 0.0932

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0030218 VERIFIED: NO

Provenance & Taxonomy

OrganismOvis ammon [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence