Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length480 amino acids

Chemical FormulaC2405H3733N625O674S18

DescriptionStandard

        MDFAYRLTLLFSIAAFVGTADAENPGLVVRVTQKGLDYALQEGVIALQQQLSHIQLKDISGTYGLGFLGHANYKFFSMNLGNVQLPGFQVSPIPNVGLKLSTSGGFFEVNGRWDVRYSFIHEDGTFNLKVGGLGMSIGLNLRNIEHGKPTVSVADCSCRIANVEVHMSGTIGWLVELFHGAVESEIRKELENKICPEVNKFINSDVSSFLRNQPVNKKIDHISGLDYSLMGPPSVMANWVDVFVKGKFYGMSHIHHPPIFAPPLTPPAMSLPPEQDHMVYFAVSDYVFNTALLTYQRAGALVLTLTDNMIPKKFGIHLDTNLLQRVIPSVSKMYPNMPMKLEMSAASTPALNINPGGVTLSPVGNIQAYAILPNSSLAPLFLLQAKTNAFAKVAVNSGNVVLSLENGNVEVSLSHSDVGPFSVSEINKLMNLFVPVVLPHVNDFLRNGFPLTFIEHIQLRDIVIKTYEHYLLFGANVHYH
    

Molecular Weight52763.32 Da

Isoelectric Point (pI)6.52

Net Charge (pH 7.0)-2.92

Net Charge (pH 7.4) -4.19

Charge Density (pH 7.0) -0.0061

GRAVY Index0.14

Hydrophobic Moment 0.71

Boman Index0.19

Instability Index45.16

Aliphatic Index 100.46

Aromaticity 0.0958

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 38975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0026972 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence