Peptide Database

Peptide NameSLAY-screened peptide P4159

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC96H161N27O28

DescriptionStandard

        SPVSYNAPLLRLIERTVVN
    

Molecular Weight2141.47 Da

Isoelectric Point (pI)8.46

Net Charge (pH 7.0)0.46

Net Charge (pH 7.4) 0.25

Charge Density (pH 7.0) 0.0243

GRAVY Index0.21

Hydrophobic Moment 0.71

Boman Index0.06

Instability Index86.14

Aliphatic Index 133.16

Aromaticity 0.0526

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 897.74

LogP -8.23

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 66.0

Heavy Atoms 151.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366362 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/