Peptide Database

Peptide Namestem cell factor

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length248 amino acids

Chemical FormulaC1240H1969N327O383S10

DescriptionStandard

        EGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMVVQLSDSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAMALPALFSLIIGFAFGALYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV
    

Molecular Weight27906.51 Da

Isoelectric Point (pI)5.27

Net Charge (pH 7.0)-4.98

Net Charge (pH 7.4) -5.39

Charge Density (pH 7.0) -0.0201

GRAVY Index-0.27

Hydrophobic Moment 0.87

Boman Index-0.02

Instability Index51.58

Aliphatic Index 87.98

Aromaticity 0.0806

Extinction Coeff. Reduced 22460.00

Extinction Coeff. Oxidized 22710.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0313267 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPartial N linked glycosylation of asparagine residues at positions 65 and 93, N-linked glycosylation of asparagine at position 120; O-linked glycosylation of serine at position 142, and of threonine at positions 143 and 155. Disulphide bond formation between cysteine residues at positions 4 and 89, and 43 and 138. Predicted N-linked glycosylation of asparagine at position 170

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetKIT proto-oncogene, receptor tyrosine kinase (Human)

Activity0.15-0.24 nM

MethodKd