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MYP_093958
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Basic Information
Bac5 (1-17)[F2W; P4,9,17R; I6W]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C114H175N43O19
Standard
Sequence
RWRRPWRRRPIRPPFYR
Physicochemical Analysis
2451.89 Da
12.00
7.76
7.55
0.4564
-2.25
0.53
-0.90
208.37
22.94
0.2353
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1040.77
-6.03
41.0
27.0
71.0
176.0
10.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0114399 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal],synthetic construct [Synthetic]
Cathelicidin, Bac5, Proline-rich antimicrobial peptide (PrAMP)
9913;32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
F2W; P4R; I6W; P9R; P17R
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli BW25113
8 μM
MIC
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0126095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii. ChemMedChem. 2019 Dec 17;14(24):2025-2033. doi: 10.1002/cmdc.201900465. PMID: 31692278. PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0171922 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MEC-1
22 %
Cytotoxicity
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii. ChemMedChem. 2019 Dec 17;14(24):2025-2033. doi: 10.1002/cmdc.201900465. PMID: 31692278. PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0370504 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii. ChemMedChem. 2019 Dec 17;14(24):2025-2033. doi: 10.1002/cmdc.201900465. PMID: 31692278. PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/