Peptide Database

Peptide NamePhospholipase A2; membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non-pancreatic secretory phospholipase A2) (NPS-PLA2) (Phosphatidylcholine 2-acylhydrolase 2A)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Bacteriolytic activity ▸ Bacteriolytic enzyme

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length144 amino acids

Chemical FormulaC692H1104N208O200S17

DescriptionStandard

        MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
    

Molecular Weight16082.55 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)15.79

Net Charge (pH 7.4) 15.08

Charge Density (pH 7.0) 0.1096

GRAVY Index-0.40

Hydrophobic Moment 0.56

Boman Index-0.10

Instability Index35.80

Aliphatic Index 58.33

Aromaticity 0.0972

Extinction Coeff. Reduced 11920.00

Extinction Coeff. Oxidized 12795.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6649.69

LogP -77.51

H-bond Donors 253.0

H-bond Acceptors 238.0

Rotatable Bonds 542.0

Heavy Atoms 1117.0

Ring Count 21.0

Amide Bonds 153.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011989 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyPhospholipase A2

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriolytic enzyme Anti-Gram-positive Hydrolase Non-hemolytic

TargetGram Positive Bacteria