Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2313H3717N585O669S18

DescriptionStandard

        MFLCCWLGLVALIPTTLSTNPGVKVRLTEKGIEYGRQLGMAVIQQKLGSIKIPDFSGTEKVSPIGKVQYSLSNMHIVNVGLPKSSVDLVPGTGVTLSIGDAFISLNGNWRVKYLRIIKDSGSFDLDVNGLSIATTISIKSDETGRPAVSSDSCSATVGSAKVKFHGGASWLYNLFTTFIDKALRNALQKQICPLVADAVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSLIDLSLKGEFYNIGKHQEPPFSPAAFNLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSITDDMIPKSSPIRLNTKTFGAFIPQIAKQFPGLMMKLLVKTVKTPTLTFQPNNATVQAITTVTAFAIQPNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLDKSYVGDFQVGPLENVFQGVLKLVVIPAVNAQLAKGYPLPTIGKMKLMNTQLDVLKDYILIGTDVQFS
    

Molecular Weight51001.94 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)9.73

Net Charge (pH 7.4) 9.20

Charge Density (pH 7.0) 0.0206

GRAVY Index0.22

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index29.94

Aliphatic Index 104.07

Aromaticity 0.0784

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0313614 VERIFIED: NO

Provenance & Taxonomy

OrganismMaylandia zebra [Bacterium]

FamilyBPI

Tax ID106582

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence