Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length462 amino acids

Chemical FormulaC2278H3674N584O647S19

DescriptionStandard

        MFLCCWLALVALIPTTVSINPGVKVKLTEKGLEYGRDLGMATIQQKLKTIKVPDMSGEQRVSPIGKVHYSLTNMHIVNVGLPKSAVDLVPGTGVRLSITNAFISLQGNWRVKYLRIIKDSGSFDLNVNGLTITSSIAIKSDETGRPAVSSVNCAATVSKASIKFHGGASWLYNLFSKFIDKALRNALQNKICPLVADAISDLNPHLKTLNVLAKVDPYAEIEYSMVSSPTVSKSSIDFSLKGEFYNIGKHQEPPFSPKPFTLAPQINNMLYIGVSAFTTNSAAFVYNKAGALSLAITDDMIPQSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVKTVKDPIITFETNNMTVQAIGTVTAYAIQPNATLSPLFVLNMVGYTTGKKKASVMDLTLGTSYVGDFQVGSLDNILQMVLKVVVIPKLNVQLAKGYPLPTLGKMKLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight50204.30 Da

Isoelectric Point (pI)9.58

Net Charge (pH 7.0)17.89

Net Charge (pH 7.4) 17.26

Charge Density (pH 7.0) 0.0387

GRAVY Index0.19

Hydrophobic Moment 0.84

Boman Index0.16

Instability Index31.28

Aliphatic Index 103.57

Aromaticity 0.0779

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0383237 VERIFIED: NO

Provenance & Taxonomy

OrganismDicentrarchus labrax [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence