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MYP_093741
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C101H180N34O21
Standard
Sequence
KNLRRIIRKGIHIIKKYG
Physicochemical Analysis
2206.72 Da
11.75
6.84
6.58
0.3801
-0.64
0.96
-0.31
64.37
130.00
0.0556
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
939.80
-5.73
35.0
29.0
81.0
156.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0057449 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Human cervical carcinoma ME-180[30-40% Cytotoxicity = 200 microg/ml]
PMID21377841 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21377841/
RECORD: Rec_0085825 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli K91BK
100
IC50
PMID21377841 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21377841/
RECORD: Rec_0098638 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei 427 (procyclic form)
50 μM
Percent inhibition; MTT assay
PaperKilling of African trypanosomes by antimicrobial peptides PMID12825184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12825184/
RECORD: Rec_0107729 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPDB 1HU6 structural record; NMR; chain A; residues 1-18
RECORD: Rec_0121227 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei 427 (blood stage form)
50 μM
Percent inhibition; MTT assay
PaperKilling of African trypanosomes by antimicrobial peptides PMID12825184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12825184/
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