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MYP_093715
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Basic Information
Kalata-B1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
29 amino acids
C117H187N35O40S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCTCSWPVCTRN
Physicochemical Analysis
2916.34 Da
5.96
-0.30
-0.59
-0.0102
0.15
0.25
0.15
46.59
43.45
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.26
46.0
46.0
84.0
198.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0308475 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19, 9-21, 14-26
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
Candida kefyr
21.4 μM
MIC
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18008336;10430870;7703226;17534989;23129773 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0312814 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Cyclotide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID21928440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928440/
RECORD: Rec_0318657 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]; Viola yedoensis [Plant]
Cyclotide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
all-D amino-acid peptide [D]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anticancer Cytotoxic Hemolytic Nematocidal Anthelmintic Molluscicidal Membrane-Binding Metal-binding Insecticidal Enzymatic-digestion Anti-HIV Enzyme inhibitory Anti-Gram-negative
Escherichia coli
160 μM
MIC
PaperPubMed PMID 21928440 | PubMed PMID 10430870 | Conlan BF et al. 2011 Am J Bot 98:2018-26 | Sando L. et al. 2011 Chembiochem 12: 2456-62 | Shenkarrev ZO et al. 2006 FEBS J 273:2658-72 | Huang et al 2009 JBC 284: 20699-20707 | Plan MR et al 2007 Chembiochem 8:1001-11 | Hellinger R et al., 2015 | Hall et al., 2012 Biochim Biophys Acta 1818:2354 PMID21928440;10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928440/
RECORD: Rec_0319682 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
160 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0324620 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
60225
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
D-amino-acid content reported
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Insecticidal
C.tropicalis
>500 μM
MIC
PaperAn unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.
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