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MYP_093715
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Basic Information
Kalata-B1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
29 amino acids
C117H187N35O40S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCTCSWPVCTRN
Physicochemical Analysis
2916.34 Da
5.96
-0.30
-0.59
-0.0102
0.15
0.25
0.15
46.59
43.45
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.26
46.0
46.0
84.0
198.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283805 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
60225
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
D-amino-acid content reported
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Insecticidal
Candida albicans
>500 μM
MIC
PaperAn unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.
RECORD: Rec_0287218 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Pesticidal
Human erythrocytes
20±1.1 μM
Paperhttps://pubmed.ncbi.nlm.nih.gov/20564013/ PMID20564013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564013/
RECORD: Rec_0288029 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19, 9-21, 14-26
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral Cytotoxic Anticancer
CEM-SS cells
3.5 μM
IC50
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18008336;10430870;7703226;17534989;23129773 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0298071 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]; Viola yedoensis [Plant]
Cyclotide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
all-D amino-acid peptide [D]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anticancer Cytotoxic Hemolytic Nematocidal Anthelmintic Molluscicidal Membrane-Binding Metal-binding Insecticidal Enzymatic-digestion Anti-HIV Enzyme inhibitory
Candida albicans
160 μM
MIC
PaperPubMed PMID 21928440 | PubMed PMID 10430870 | Conlan BF et al. 2011 Am J Bot 98:2018-26 | Sando L. et al. 2011 Chembiochem 12: 2456-62 | Shenkarrev ZO et al. 2006 FEBS J 273:2658-72 | Huang et al 2009 JBC 284: 20699-20707 | Plan MR et al 2007 Chembiochem 8:1001-11 | Hellinger R et al., 2015 | Hall et al., 2012 Biochim Biophys Acta 1818:2354 PMID21928440;10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928440/
RECORD: Rec_0302715 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
W at position 23 is oxidated
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Toxic Anti-Gram-positive Cytotoxic Insecticidal
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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