Peptide Database

Peptide NameKalata-B1

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Anthelminthic

Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Binding / Molecular interaction ▸ Binding activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Insecticidal/Pest control ▸ Insecticidal activity

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC117H187N35O40S6

DescriptionStandard

        GLPVCGETCVGGTCNTPGCTCSWPVCTRN
    

Molecular Weight2916.34 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.30

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0102

GRAVY Index0.15

Hydrophobic Moment 0.25

Boman Index0.15

Instability Index46.59

Aliphatic Index 43.45

Aromaticity 0.0345

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1174.30

LogP -18.26

H-bond Donors 46.0

H-bond Acceptors 46.0

Rotatable Bonds 84.0

Heavy Atoms 198.0

Ring Count 5.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0000929 VERIFIED: YES

Provenance & Taxonomy

OrganismOldenlandia affinis [Plant]; Viola yedoensis [Plant]

FamilyCyclotide

Tax ID60225

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

Disulfidedisulfide bond reported, sites not specified

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Antiviral Anticancer Cytotoxic Hemolytic Nematocidal Anthelmintic Molluscicidal Membrane-Binding Metal-binding Insecticidal Enzymatic-digestion Anti-HIV Enzyme inhibitory

TargetCandida tropicalis

Activity500 μM

MethodMIC

PaperPubMed PMID 21928440 | PubMed PMID 10430870 | Conlan BF et al. 2011 Am J Bot 98:2018-26 | Sando L. et al. 2011 Chembiochem 12: 2456-62 | Shenkarrev ZO et al. 2006 FEBS J 273:2658-72 | Huang et al 2009 JBC 284: 20699-20707 | Plan MR et al 2007 Chembiochem 8:1001-11 | Hellinger R et al., 2015 | Hall et al., 2012 Biochim Biophys Acta 1818:2354 PMID21928440;10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928440/

RECORD: Rec_0014246 VERIFIED: YES

Provenance & Taxonomy

OrganismOldenlandia affinis [Plant]; Viola yedoensis [Plant]

FamilyCyclotide

Tax ID60225

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

Disulfidedisulfide bond reported, sites not specified

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Antiviral Anticancer Cytotoxic Hemolytic Nematocidal Anthelmintic Molluscicidal Membrane-Binding Metal-binding Insecticidal Enzymatic-digestion Anti-HIV Enzyme inhibitory Anti-Gram-positive

TargetMicrococcus luteus

Activity40.4 μM

MethodMIC

PaperPubMed PMID 21928440 | PubMed PMID 10430870 | Conlan BF et al. 2011 Am J Bot 98:2018-26 | Sando L. et al. 2011 Chembiochem 12: 2456-62 | Shenkarrev ZO et al. 2006 FEBS J 273:2658-72 | Huang et al 2009 JBC 284: 20699-20707 | Plan MR et al 2007 Chembiochem 8:1001-11 | Hellinger R et al., 2015 | Hall et al., 2012 Biochim Biophys Acta 1818:2354 PMID21928440;10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928440/

RECORD: Rec_0023226 VERIFIED: YES

Provenance & Taxonomy

OrganismOldenlandia affinis [Plant]; Viola yedoensis [Plant]

FamilyCyclotide

Tax ID60225

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

Disulfidedisulfide bond reported, sites not specified

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Antiviral Anticancer Cytotoxic Hemolytic Nematocidal Anthelmintic Molluscicidal Membrane-Binding Metal-binding Insecticidal Enzymatic-digestion Anti-HIV Enzyme inhibitory Anti-Gram-negative

TargetPseudomonas aeruginosa

Activity10 μM

MethodMIC

PaperPubMed PMID 21928440 | PubMed PMID 10430870 | Conlan BF et al. 2011 Am J Bot 98:2018-26 | Sando L. et al. 2011 Chembiochem 12: 2456-62 | Shenkarrev ZO et al. 2006 FEBS J 273:2658-72 | Huang et al 2009 JBC 284: 20699-20707 | Plan MR et al 2007 Chembiochem 8:1001-11 | Hellinger R et al., 2015 | Hall et al., 2012 Biochim Biophys Acta 1818:2354 PMID21928440;10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928440/

RECORD: Rec_0026757 VERIFIED: YES

Provenance & Taxonomy

OrganismOldenlandia affinis [Plant]

FamilyCyclotide

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetHuman blood type A erythrocytes

MethodHemolysis

RECORD: Rec_0031107 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCyclotide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitymixed L/D or modified amino-acid peptide [Mixed]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

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