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MYP_093630
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Basic Information
Palustrin-2c
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
31 amino acids
C135H233N39O43S2
Standard
Sequence
GFLSTVKNLATNVAGTVIDTLKCKVTGGCRS
Physicochemical Analysis
3154.66 Da
9.39
2.74
2.50
0.0883
0.35
0.48
0.12
3.51
94.19
0.0323
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1341.37
-17.82
50.0
48.0
106.0
219.0
1.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0212140 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Non-hemolytic
Gram-negative bacteria
PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0283687 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Palustrin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
120.0 μM
MIC
PaperY.J. Basir et al. / Biochimica et Biophysica Acta 1543 (2000) 95-105. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0307877 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
298395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-29
Bio-Activity Profile
Antimicrobial
Escherichia coli
120 μM
MIC
PaperMultiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0310808 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0365016 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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