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MYP_093609
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Basic Information
Human beta-defensin 2 (hBD-2; Defensin, beta 2; Beta-defensin 4A; Human, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Wound healing/Regeneration ▸ Wound healing
Standard
41 amino acids
C188H311N55O50S6
Standard
Sequence
GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
Physicochemical Analysis
4334.21 Da
9.30
5.78
5.43
0.1410
-0.10
0.52
0.02
42.29
64.15
0.0488
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1647.49
-17.55
62.0
63.0
137.0
299.0
8.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0174754 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
8-37, 15-30, 20-38
C37, C15:C30, C20:C38
Bio-Activity Profile
Antimicrobial Antibacterial
PMID23000475 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23000475/
RECORD: Rec_0179676 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-37, 15-30, 20-38
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Hemolytic
PMID9202117;10906336;17340092 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9202117/
RECORD: Rec_0213223 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-37, 15-30, 20-38
Disulfide bonds between Cys8 and Cys37, Cys15 and Cys30, Cys20 and Cys38.
Bio-Activity Profile
Antiviral Anti-HIV-1 Infection inhibition
HIV-1 IIIB | TZM-bl cells
3.1 μg/mL
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperHuman beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. | Sun L, Finnegan CM, Kish-Catalone T, Blumenthal R, Garzino-Demo P, La Terra Maggiore GM, Berrone S, Kleinman C, Wu Z, Abdelwahab S, Lu W, Garzino-Demo A. | J Virol. 2005 Nov;79(22):14318-29. | DOI:10.1128/JVI.79.22.14318-14329.2005 | PMID:16254366 PMID16254366 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16254366/
RECORD: Rec_0244112 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-37, 15-30, 20-38
Disulfide bonds between Cys8 and Cys37, Cys15 and Cys30, Cys20 and Cys38.
Bio-Activity Profile
Antiviral Anti-HIV-1 Infection inhibition
HIV-1 BaL | TZM-bl cells
6.2 μg/mL
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperHuman beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. | Sun L, Finnegan CM, Kish-Catalone T, Blumenthal R, Garzino-Demo P, La Terra Maggiore GM, Berrone S, Kleinman C, Wu Z, Abdelwahab S, Lu W, Garzino-Demo A. | J Virol. 2005 Nov;79(22):14318-29. | DOI:10.1128/JVI.79.22.14318-14329.2005 | PMID:16254366 PMID16254366 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16254366/
RECORD: Rec_0255100 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-37
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Wound healing
Staphylococcus aureus ATCC 25923
100 μg/mL
MIC
PaperA peptide antibiotic from human skin
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