Peptide Database

Peptide NameSLAY-screened peptide P4331

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC86H147N25O21S3

DescriptionStandard

        ACGIPLIRARSICLFCLN
    

Molecular Weight1963.44 Da

Isoelectric Point (pI)8.74

Net Charge (pH 7.0)1.77

Net Charge (pH 7.4) 1.53

Charge Density (pH 7.0) 0.0981

GRAVY Index1.31

Hydrophobic Moment 0.22

Boman Index0.29

Instability Index73.35

Aliphatic Index 141.11

Aromaticity 0.0556

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 736.35

LogP -5.48

H-bond Donors 29.0

H-bond Acceptors 26.0

Rotatable Bonds 62.0

Heavy Atoms 135.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288846 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/