Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2193H3470N588O617S9

DescriptionStandard

        VHPGFVVRITQAGLDYARQHGVSILEKELGQLRLPDISGHFRVRKVGKVRYEISSLDLRSFRLPSSQISPLPDVGLQVSISNAFAEVDGDWRVKVHFIRDHGSFDLRVEDLSIRINLKLGSDASGKPTADASYCSTHISSVHIHFSGKLSWLYNLFHSAIESRFRSILESKVCENVVSSVRSELQPYLQTLPVTAKIDAVAGIDYSLVAPPAATVQSLDADLKGEFFSLAHRAAVPFPPPPLAFPPDHARMVYLGVSSYFFNTAGLVYHAAGALVFELTDSMIPKGLDFHLNTSTFSAFVPQLEKLYPDMLMKLRLSTPAAPSLSIGPKGLSLRPVVDIQAYAILPSSSLAPLFLLNLVTNVSASIDVKSSRIVGNVTVGRLKLFPSPLSVSQVRMLQSIMNIFTSSILLPRLNARFGQGFPLPLPDRIQLSDIVMQSHQ
    

Molecular Weight48233.16 Da

Isoelectric Point (pI)9.21

Net Charge (pH 7.0)6.97

Net Charge (pH 7.4) 5.94

Charge Density (pH 7.0) 0.0158

GRAVY Index0.16

Hydrophobic Moment 0.71

Boman Index0.13

Instability Index42.76

Aliphatic Index 105.66

Aromaticity 0.0841

Extinction Coeff. Reduced 27390.00

Extinction Coeff. Oxidized 27515.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0041625 VERIFIED: NO

Provenance & Taxonomy

OrganismDromaius novaehollandiae [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria