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MYP_093452
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Basic Information
Aborycin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Standard
21 amino acids
C97H137N23O27S4
Standard
Sequence
CLGIGSCNDFAGCGYAVVCFW
Physicochemical Analysis
2185.52 Da
4.05
-1.28
-1.54
-0.0609
1.16
0.28
0.50
33.82
74.29
0.1905
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
781.96
-6.72
31.0
30.0
64.0
151.0
5.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022237 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. SCSIO ZS0098 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus Sau 29213
8 μg/mL
MIC
PMID30795576 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30795576/
RECORD: Rec_0029769 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. SCSIO ZS0098 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii ATCC 19606
128 μg/mL
MIC
PMID30795576 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30795576/
RECORD: Rec_0036633 VERIFIED: YES
Provenance & Taxonomy
Streptomyces strains [Bacterium]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19. In contrast. Class 2 lassos do not have disulfide bonds
Bio-Activity Profile
Antiviral
PaperIsolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.
RECORD: Rec_0041762 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 19.0%, T 47.6%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0069516 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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