Peptide Database

Peptide NameSLAY-screened peptide P4635

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC125H194N32O24

DescriptionStandard

        TPFRVFWLLGLIGIRIPRFLN
    

Molecular Weight2529.08 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.40

Net Charge (pH 7.4) 2.21

Charge Density (pH 7.0) 0.1142

GRAVY Index0.89

Hydrophobic Moment 0.52

Boman Index0.32

Instability Index15.57

Aliphatic Index 143.81

Aromaticity 0.1905

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 892.55

LogP -1.15

H-bond Donors 32.0

H-bond Acceptors 27.0

Rotatable Bonds 77.0

Heavy Atoms 181.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207432 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/