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MYP_093386
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Basic Information
Dermadistinctin-L
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C130H221N37O37S
Standard
Sequence
ALWKTLLKNVGKAAGKAALNAVTDMVNQ
Physicochemical Analysis
2926.44 Da
10.00
2.79
2.60
0.0998
0.15
0.65
0.12
0.25
108.21
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1219.01
-11.86
41.0
41.0
100.0
205.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0241156 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa duellmani [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0245359 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal Hemolytic
human blood
PMID10477123;12379643;17409003;17442605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0245422 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Candida albicans
PMID10477123;12379643;17409003;17442605;18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0261667 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Candida tropicalis
PMID10477123;12379643;17409003;17442605;18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0280170 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Enterococcus faecalis
10 μM
MIC
PMID10477123;12379643;17409003;17442605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
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