Peptide Database

Peptide NameDermadistinctin-L

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC130H221N37O37S

DescriptionStandard

        ALWKTLLKNVGKAAGKAALNAVTDMVNQ
    

Molecular Weight2926.44 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)2.79

Net Charge (pH 7.4) 2.60

Charge Density (pH 7.0) 0.0998

GRAVY Index0.15

Hydrophobic Moment 0.65

Boman Index0.12

Instability Index0.25

Aliphatic Index 108.21

Aromaticity 0.0357

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1219.01

LogP -11.86

H-bond Donors 41.0

H-bond Acceptors 41.0

Rotatable Bonds 100.0

Heavy Atoms 205.0

Ring Count 2.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108954 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative

TargetC.guilliermondii

RECORD: Rec_0124284 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

RECORD: Rec_0127813 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal

RECORD: Rec_0150361 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0185392 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEnterococcus faecalis

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