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MYP_093374
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Basic Information
Wollamide B [V4Me-Val]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
6 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WLLXNX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0137102 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 4,6
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 29213
12.5 μg/mL
MIC
PMID25229313;29431987;28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0206456 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 4,6
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis ATCC 6051
1.8 μM
IC50
PMID25229313;29431987;28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0209185 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 4,6
Bio-Activity Profile
Hemolytic
Vero cells (IC50 at 407 microg/ml
50 μg/mL
Hemolysis
PMID25229313;29431987;28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0210490 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 4,6
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis ATCC 14990
12.5 μg/mL
MIC
PMID25229313;29431987;28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0221572 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. [Bacterium]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
X=Allo-Ile; x=D-Orn
Bio-Activity Profile
Antimicrobial Anticancer
(Not active up to 30 μM)
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
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