Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length469 amino acids

Chemical FormulaC2393H3799N619O669S15

DescriptionStandard

        MLLQQRGEQRVTVWTINPGFEGKITNRGINYGCQIVMSVLQNRLFDIKIPDISGIKHTNALHQLQYNIDSVTIRNVNLPDMSIILVPNMGLKVAMSNGYIETNGNWLIKSKIFRTHGTVKAQINNIAISFFLKFGKDNTGRPTVSITDCASYISKLHIYVSGKASWLYNLIIRWHEPSLRRYLNDKICLELQEILSEKINPFLQTMPVTKKIDKYVGIDYSLTSPPAVGKDSVTLPLKGEFYNLLHHTNVPFSAPPLDFLVDHGRMLYIGFSEYFFNSAGYAFNSVGDLSINITDDMLPTNSRIHLDTATIGTLIPQVKKMYPIMKMKLHLVSDSAPSVALLADKIILTTSGDIYAFAILPNSTLAPLFNIKLNAQITTTIGIKGDKITGQLTLDRVQLSLKKSHIGSFQVNCLQTAIDFLVSIVILPRINAALDDGYPLPLIGHFKLSNLIVQPHKNFLLFATDLSYT
    

Molecular Weight52425.48 Da

Isoelectric Point (pI)9.21

Net Charge (pH 7.0)10.60

Net Charge (pH 7.4) 9.57

Charge Density (pH 7.0) 0.0226

GRAVY Index0.10

Hydrophobic Moment 0.69

Boman Index0.14

Instability Index32.69

Aliphatic Index 109.74

Aromaticity 0.0896

Extinction Coeff. Reduced 47330.00

Extinction Coeff. Oxidized 47580.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0283836 VERIFIED: NO

Provenance & Taxonomy

OrganismScyliorhinus torazame [Bacterium]

FamilyBPI

Tax ID75743

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence